Author Affiliations
Abstract
1 State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
2 National–Local Joint Engineering Laboratory of New Energy Photovoltaic Devices, Key Laboratory of Digital Medical Engineering of Hebei Province, College of Electron and Information Engineering, Hebei University, Baoding 071002, China
3 College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
New neuromorphic architectures and memory technologies with low power consumption, scalability and high-speed are in the spotlight due to the von Neumann bottleneck and limitations of Moore's law. The memristor, a two-terminal synaptic device, shows powerful capabilities in neuromorphic computing and information storage applications. Active materials with high defect migration speed and low defect migration barrier are highly promising for high-performance memristors. Halide perovskite (HP) materials with point defects (such as gaps, vacancies, and inversions) have strong application potential in memristors. In this article, we review recent advances on HP memristors with exceptional performances. First, the working mechanisms of memristors are described. Then, the structures and properties of HPs are explained. Both electrical and photonic HP-based memristors are overviewed and discussed. Different fabrication methods of HP memristor devices and arrays are described and compared. Finally, the challenges in integrating HP memristors with complementary metal oxide semiconductors (CMOS) are briefly discussed. This review can assist in developing HP memristors for the next-generation information technology.
Journal of Semiconductors
2020, 41(5): 051205
1 中国科学院 高能物理研究所， 北京 100049
2 中国科学院大学， 北京 100049
Laue晶体单色器常用于单色化高能X射线（＞50 keV），通过对其晶片压弯可以实现高能光束聚焦。晶片压弯过程中会不可避免地产生扭曲，从而影响单色器的工作效率。利用波动光学仿真的方法，分析弯晶面形扭曲对Laue晶体单色器性能的影响，并提出一种角位移微调轴角装置，用来消除这种扭曲。该装置基于直梁型柔性铰链，利用叠加原理和对称结构。利用有限元方法分析了该装置的力学性能。分析结果表明，轴角装置的转角范围为±2°时，其转动中心最大偏移为20 μm，实现了角位移分辨率好于1″，动态范围达到104，达到设计目标。
Laue晶体单色器 光学仿真 轴角装置 柔性铰链 压弯机构 Laue crystal monochromator optical simulation rotary mechanism flexure hinge bending mechanism 强激光与粒子束
2019, 31(9): 091003
Author Affiliations
Abstract
1 College of Engineering, Huazhong Agricultural University, Wuhan 430070, P. R. China
2 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, P. R. China
3 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China
4 Bio-Medical Center, Huazhong Agricultural University, Wuhan 430070, P. R. China
5 Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, P. R. China
Traditionally, optical microscopy is used to visualize the morphological features of pathogenic bacteria, of which the features are further used for the detection and identification of the bacteria. However, due to the resolution limitation of conventional optical microscopy as well as the lack of standard pattern library for bacteria identification, the effectiveness of this optical microscopybased method is limited. Here, we reported a pilot study on a combined use of Structured Illumination Microscopy (SIM) with machine learning for rapid bacteria identification. After applying machine learning to the SIM image datasets from three model bacteria (including Escherichia coli, Mycobacterium smegmatis, and Pseudomonas aeruginosa), we obtained a classification accuracy of up to 98%. This study points out a promising possibility for rapid bacterial identification by morphological features.
Structured illumination microscopy bacterial classification principal component analysis support vector machine random forest Journal of Innovative Optical Health Sciences
2018, 11(1): 1850007
Author Affiliations
Abstract
1 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P. R. China
2 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, P. R. China
3 Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China
4 Convergence Technology Co. Ltd, 1037 Luoyu Road, Hongshan District, Wuhan 430074, P. R. China
5 Bio-Medical center, Huazhong Agricultural University, Wuhan 430070, P. R. China
6 Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, P. R. China
In vivo fiber photometry is a powerful technique to analyze the dynamics of population neurons during functional study of neuroscience. Here, we introduced a detailed protocol for fiber photometry-based calcium recording in freely moving mice, covering from virus injection, fiber stub insertion, optogenetical stimulation to data procurement and analysis. Furthermore, we applied this protocol to explore neuronal activity of mice lateral-posterior (LP) thalamic nucleus in response to optogenetical stimulation of primary visual cortex (V1) neurons, and explore axon clusters activity of optogenetically evoked V1 neurons. Final confirmation of virus-based protein expression in V1 and precise fiber insertion indicated that the surgery procedure of this protocol is reliable for functional calcium recording. The scripts for data analysis and some tips in our protocol are provided in details. Together, this protocol is simple, low-cost, and effective for neuronal activity detection by fiber photometry, which will help neuroscience researchers to carry out functional and behavioral study in vivo.
Fiber photometry surgical operation optogenetical stimulation neural activity freely moving recording. Journal of Innovative Optical Health Sciences
2017, 10(5): 1743001
1 中国环境科学研究院水污染控制技术研究中心, 北京 100012
2 环境基准与风险评估国家重点实验室, 中国环境科学研究院, 北京 100012
3 中国矿业大学(北京)化学与环境工程学院, 北京 100083
4 中国石油吉林石化分公司电石厂, 吉林省 吉林市 132022
以回收实际丙烯酸丁酯废水有机酸的双极膜电渗析膜堆中的阴离子交换膜为研究对象, 对膜使用前后的性能进行了表征, 并综合通过衰减全反射傅里叶变换红外光谱（ATR-FTIR）、 扫描电镜-能谱（SEM-EDS）和X射线光电子能谱（XPS）等手段对膜表面组分变化进行了表征。 膜性能分析结果表明, 使用后的阴离子交换膜受到污染, 膜电阻增大, 迁移数减小。 能谱分析结果表明, 使用后阴离子交换膜表面污染物C和O元素含量（以原子百分比计）显著升高, 分别从78.10%, 8.34%升高到81.76%, 12.05%, 表明膜污染物为含碳含氧物质。 XPS谱图C1s峰的分析表明, —COO-Na+化学态的百分含量从污染前的8.5%升高到污染后的13.7%, 表明膜污染物中含有—COO-Na+。 ATR-FTIR分析结果表明, 阴离子交换膜使用后, 在1 561 cm-1处的吸收增强, 而此波长正是—COO-M+（M为金属）的反对称伸缩振动峰, 进一步验证了XPS分析结果。 由于丙烯酸丁酯废水中含有聚丙烯酸钠, 因此采用聚丙烯酸钠溶液污染阴离子交换膜, 并对污染后离子交换膜进行膜性能、 XPS和ATR-FTIR的分析。 结果表明, 聚丙烯酸钠导致阴离子交换膜膜电阻增大, 迁移数减小, XPS谱图—COO-Na+化学态的百分含量增加, ATR-FTIR谱图1 561 cm-1处吸收增强。 综合上述结果, 聚丙烯酸钠是废水中造成阴离子交换膜污染的重要物质。 光谱分析方法是离子交换膜污染层表征和污染物鉴别的有效手段。
聚丙烯酸钠 双极膜电渗析 阴离子交换膜 膜污染 光谱分析 Polyacrylate sodium Bipolar membrane electrodialysis Anion-exchange membrane Membrane fouling Spectral analysis 光谱学与光谱分析
2017, 37(9): 2832
1 福建师范大学, 医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建 福州 350007
2 福建省妇幼保健院生殖研究室, 福建 福州 350001
拉曼光谱通过记录光与物质作用时频率的改变, 进而获得物质分子振动、 转动信息, 从而实现物质分子结构及其变化的检测。 相比于常规生化检测分析方法, 拉曼光谱技术具有无损、 非标记检测及对检测样品要求低等优点。 拉曼光谱技术已广泛应用于生物医学领域的研究, 如人体组织、 器官、 细胞以及人体体液的各种疾病诊断、 检测研究。 本文主要综述了拉曼光谱技术在人体精液的研究进展, 首先介绍了拉曼光谱技术(包含表面增强拉曼光谱)在法医学领域针对精液整体开展的研究及相关的数据处理方法, 然后重点介绍拉曼光谱在男性生殖生育方面的研究, 即分别介绍了可客观反映精液质量及男性生殖生育能力的基于精液(精浆)拉曼光谱的定性和定量检测分析; 另外, 介绍了基于显微拉曼光谱技术开展的单精子水平的精子质量的刻画和评估, 以及目前研究初步获得的有望用于优质精子判别的拉曼光谱标记指标, 最后展望了拉曼光谱技术在生殖生育领域的应用发展前景。
精子 精浆 拉曼光谱 表面增强拉曼散射(SERS) 诊断检测 定量分析 Spermatozoa Seminal plasma Raman spectroscopy Surface-enhanced Raman spectroscopy Diagnosis Quantitative analysis 光谱学与光谱分析
2016, 36(9): 2818
1 医学光电科学与技术教育部重点实验室,福州 350007
2 福建省妇幼保健院,福州 350001
本文介绍浸泡法制备基于滤纸的SERS基底,并分析滤纸SERS基底表面银纳米粒子(AgNP)的分布与浸泡时间的关系。以精浆为检测对象,相比于514 nm波长激发，785 nm激发可获得更好的光谱数据，同时还比较了该波长激发下精浆的常规拉曼光谱与SERS光谱。更为重要的是,通过采用精浆中654 cm-1谱峰强度评估不同浸泡时间下(6 h,12 h,24 h)滤纸SERS基底的增强性能和测量结果的重复性。实验结果表明,12 h浸泡获得的滤纸SERS基底表面具有均匀的AgNP分布,在785 nm波长激发下,纸基SERS基底可提供增强效果及光谱重复性俱佳的精浆SERS光谱。
表面增强拉曼散射 滤纸 银纳米颗粒 精浆 surface-enhanced Raman scattering filter paper silver nanoparticles seminal plasma
